A review of modern and Vedic practices on use of umbilical cord.

Stromal cells possess unique properties to regenerate themselves and cure various chronic illnesses. An easily available and ethical source for procurement of stromal cells is umbilical cord blood which is now being stored for future use. Vedic texts also describe the cord blood as a source of life. However, Indian traditions seem to preserve one more alternative for storage and procurement of stromal cells. Traditionally, in many parts of India, the umbilical cord stump is dried and stored for future use. It is used as a medicine for some illness and to treat infertility. Since Indian traditions are an excerpt of Vedic science, it points towards the possible emergence of dried stump as an easy and cost-effective means for stromal cell procurement and storage. The present review compiles the literature available on these traditional practices and stresses upon the need of rigorous experimental and theoretical research in the area.

Understanding Meditation Based on the Subjective Experience and Traditional Goal: Implications for Current Meditation Research.

Owing to its benefits on various cognitive aspects, one's emotions, and well-being, meditation has drawn interest from several researchers and common public alike. We have different meditation practices associated with many cultures and traditions across the globe. Current literature suggests significant changes in the neural activity among the different practices of meditation, as each of these practices contributes to distinct physiological and psychological effects. Although this is the case, we want to find out if there is an underlying commonality among all these different practices. Thus, we ask the following questions related to different practices of meditation, the traditional goal of meditation and its significance-what is the central purpose of meditation? Do traditions define the final goal of all the practices of meditation? Are the purpose and goal of these practices different or is there a common goal to be attained through all these distinct practices? Embracing the traditional perspective, through this paper, we want to emphasize that, although these techniques and practices may appear different on the periphery, eventually, they seem to subject one to the same experience at the end, a natural meditative state (discussed in various spiritual traditions as the goal of meditation). In view of future studies on different meditation practices and also those exploring this subjective state, we offer some interesting ideas based on the traditional insights into meditation. In this context, we would also like to make a few comments on the way contemporary researchers view different practices of meditation.

The Role of One's Motive in Meditation Practices and Prosociality.

No individual exists without exhibiting prosociality in one or another situation during their lifetime. The argument however, is to what extent? Does it arise spontaneously, out of true empathy and compassion for others, or it is goal-oriented with some hidden motive? Here, our primary intention is to convey that, though various meditation-based interventions can be utilized for different purposes like cultivating prosocial behaviors such as compassion, empathy etc., one's underlying motive and intent seems to play a crucial role in an individual's development. Most of the studies exploring prosociality, in the context of meditation, usually do not consider the role of hidden or underlying motivation in one's prosocial expression. By considering an example of how mindfulness may sometimes lead to the wrong consequences, we try to analyze why it is important to include the aspect of inner motivation in future studies exploring the effects of meditation on prosociality. We also propose that while practicing meditation one may need traditional assistance and ethical/moral teachings in addition to those merely isolated techniques.

The 'Self' Aspects: the Sense of the Existence, Identification, and Location.

The present article is limited to research studies focused on understanding the phenomenon and construction of the concept of 'Self.' When we look at one's experience of the Self, as a whole, it involves various components associated with different aspects like self-identification, self-location and the sense of the existence of oneself or the sense of Self. While exploring the Self phenomenon, many scientific studies consider only partial aspects of the experience, and hence any understanding resulting from such an evaluation makes it difficult to comment on the nature of the Self. We emphasize that while studying the Self, to understand it totally, one would need to include all the components of the Self. In this connection, we raise the following two theses: a) Ontologically, the Self is conceived as a sentient entity, the bearer of the "what it is like to be" type of feeling, and b) Phenomenologically, we do not have a direct apprehension of the Self, but experience various aspects of the Self through the Senses of Existence, Identification, and Location.

Consciousness as an Inhibited Manifestation and Quantum Physics.

The term soul is used in the traditional literature as a synonym for one's true Self and is associated with the subjective essence of one's living. Since, we don't have any means to quantify it, the science has ruled out this idea from its investigations. But, in a recent study, Ceylan et al. (2017) has reintroduced the word soul to scientific literature and examined the possibility of the study of the soul through scientific modalities. The primary focus of their study is to find and understand the scientific analog of the soul as quoted and discussed in the traditional literature. In the present paper, we examine the idea of a soul that uses a novel approach; integrating neuroscience and quantum physics, as proposed in Ceylan et al. (2017). For this purpose, we make use of findings from neuroscientific studies on meditation to understand the concepts of soul and consciousness in terms of inhibition mechanisms. In this context, this paper serves as an attempt to call for more studies to discuss and expand the hypothesis about the soul as uninhibited mental activity.

Relevance of quantum mechanics on some aspects of ion channel function.

Mathematical modeling of ionic diffusion along K ion channels indicates that such diffusion is oscillatory, at the weak non-Markovian limit. This finding leads us to derive a Schrödinger-Langevin equation for this kind of system within the framework of stochastic quantization. The Planck's constant is shown to be relevant to the Lagrangian action at the level of a single ion channel. This sheds new light on the issue of applicability of quantum formalism to ion channel dynamics and to the physical constraints of the selectivity filter.

The 'prediction imperative' as the basis for self-awareness.

Here, we propose that global brain function is geared towards the implementation of intelligent motricity. Motricity is the only possible external manifestation of nervous system function (other than endocrine and exocrine secretion and the control of vascular tone). The intelligence component of motricity requires, for its successful wheeling, a prediction imperative to approximate the consequences of the impending motion. We address how such predictive function may originate from the dynamic properties of neuronal networks.

Non-Markovian noise mediated through anomalous diffusion within ion channels.

It is evident from a wide range of experimental findings that ion channel gating is inherently stochastic. The issue of "memory effects" (diffusional retardation due to local changes in water viscosity) in ionic flow has been recently addressed using Brownian dynamics simulations. The results presented indicate such memory effects are negligible, unless the diffusional barrier is much higher than that of free solute. In this paper using differential stochastic methods we conclude that the Markovian property of exponential dwell times gives rise to a high barrier, resulting in diffusional memory effects that cannot be ignored in determining ionic flow through channels. We have addressed this question using a generalized Langevin equation that contains a combination of Markovian and non-Markovian processes with different time scales. This approach afforded the development of an algorithm that describes an oscillatory ionic diffusional sequence. The resulting oscillatory function behavior, with exponential decay, was obtained at the weak non-Markovian limit with two distinct time scales corresponding to the processes of ionic diffusion and drift. This will be analyzed further in future studies using molecular dynamics simulations. We propose that the rise of time scales and memory effects is related to differences of shear viscosity in the cytoplasm and extracellular matrix.

Dynamic geometry, brain function modeling, and consciousness.

Pellionisz and Llinás proposed, years ago, a geometric interpretation towards understanding brain function. This interpretation assumes that the relation between the brain and the external world is determined by the ability of the central nervous system (CNS) to construct an internal model of the external world using an interactive geometrical relationship between sensory and motor expression. This approach opened new vistas not only in brain research but also in understanding the foundations of geometry itself. The approach named tensor network theory is sufficiently rich to allow specific computational modeling and addressed the issue of prediction, based on Taylor series expansion properties of the system, at the neuronal level, as a basic property of brain function. It was actually proposed that the evolutionary realm is the backbone for the development of an internal functional space that, while being purely representational, can interact successfully with the totally different world of the so-called "external reality". Now if the internal space or functional space is endowed with stochastic metric tensor properties, then there will be a dynamic correspondence between events in the external world and their specification in the internal space. We shall call this dynamic geometry since the minimal time resolution of the brain (10-15 ms), associated with 40 Hz oscillations of neurons and their network dynamics, is considered to be responsible for recognizing external events and generating the concept of simultaneity. The stochastic metric tensor in dynamic geometry can be written as five-dimensional space-time where the fifth dimension is a probability space as well as a metric space. This extra dimension is considered an imbedded degree of freedom. It is worth noticing that the above-mentioned 40 Hz oscillation is present both in awake and dream states where the central difference is the inability of phase resetting in the latter. This framework of dynamic geometry makes it possible to distinguish one individual from another. In this paper we shall investigate the role of dynamic geometry in brain function modeling and the neuronal basis of consciousness.